High-Dose Therapy and Transplantation of Haematopoietic Stem Cells

by Wolfgang Schultze

Publisher: Blackwell Publishing Limited

Written in English
Cover of: High-Dose Therapy and Transplantation of Haematopoietic Stem Cells | Wolfgang Schultze
Published: Pages: 240 Downloads: 489
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  • Haematology,
  • Oncology,
  • Medical / Nursing,
  • Medical,
  • Hematology,
  • Immunology,
  • Medical / Immunology
The Physical Object
Number of Pages240
ID Numbers
Open LibraryOL9900116M
ISBN 101405100192
ISBN 109781405100199

  Several animal studies have shown that autoimmune diseases are stem cell disorders and that transplantation of normal hematopoietic stem cells after myeloablative therapy can be used to treat these diseases. Similarly, remissions of autoimmune diseases have been reported in patients with concomitant malignancies for which they were treated Cited by: Table of Contents: When is a Stem Cell Really a Stem Cell? Gerald J. Spangrude Embryonic Stem Cells: Unique Potential to Treat Autoimmune Diseases Dan S. Kaufman and James A. Thomson Neural Stem Cells and Oligodendrocyte Progenitors in the Central Nervous System Jennifer A. Jackson and Diana L. Clarke Turning Blood into Liver Bryon E. Petersen and Neil . Get this from a library! Thomas' hematopoietic cell transplantation: stem cell transplantation. [Frederick R Appelbaum; E Donnall Thomas;] -- This reference source on bone marrow transplantation has become recognised as the bible in the field. This fourth edition has been fully revised to reflect latest developments, and now features over. High-Dose Chemotherapy and Hematopoietic Stem Cell Transplantation in Hematologic Malignancies. Roberto Rodriguez. Chatchada Karanes. The clinical practice of bone marrow transplantation was not widely used in the United States until the early s although the first successful allogeneic hematopoietic stem cell transplantation (HCT) occurred.

Hematopoietic stem cell transplantation for patients with AML in first complete remission replacing high-dose cytotoxic therapy with graft-versus-tumor effects., Maintenance therapy with low-dose azacitidine after allogeneic hematopoietic stem cell transplantation for recurrent acute myelogenous leukemia or myelodysplastic syndrome: a Cited by: Bone marrow (hematopoietic cell) transplantation in patients with non-malignant diseases and myelodysplastic syndromes What every physician needs to know about bone marrow transplantation for non.

High-Dose Therapy and Transplantation of Haematopoietic Stem Cells by Wolfgang Schultze Download PDF EPUB FB2

High-dose therapy with allogeneic or autologous stem celltransplantation as well as additional supportive measures havebrought important advances in the therapy of malignantdiseases.

Allogeneic and especially autologous peripheral blood stem cellgrafting as opposed to allogeneic bone marrow transplantation is asubject of intensive : Paperback.

"a to z" review of hematopoietic stem cell transplantation, High-Dose Therapy and Transplantation of Haematopoietic Stem Cells will be useful to readers who wish to gain a fuller understanding of the recent application of novel approaches in this continuously evolving by: 1.

Rent or Buy High Dose Therapy and Transplantation of Haemopoietic Stem Cells () - by Schultze, Wolfgang for as low as $ at Voted #1 site for Buying Edition: 2nd. Hematopoietic stem cell transplantation (HSCT) is the transplantation of multipotent hematopoietic stem cells, usually derived from bone marrow, peripheral blood, or umbilical cord blood.

It may be autologous (the patient's own stem cells are used), allogeneic (the stem cells come from a donor) or syngeneic (from an identical twin). It is most often performed for patients with certain.

International Stem Cell Workshop, High Dose Therapy and Transplantation of Haemopoietic Stem Cells (4th: Bad Saarow, Berlin, Germany). High-dose therapy and transplantation of haemopoietic stem cells.

Berlin ; Boston: Blackwell Wissenschaft, (OCoLC) Material Type: Conference publication: Document Type: Book: All Authors. these dose limitations, autologous haematopoietic stem cell transplantation (AHSCT), high-dose therapy supported by the infusion of haematopoietic stem cells, has evolved as a medical procedure to allow for administration of intense drug doses with tolerable organ and haematopoietic toxicity.

Infusion High-Dose Therapy and Transplantation of Haematopoietic Stem Cells book autologous. Remarkable developments in the field of transplantation have created opportunities to address the formidable challenges of transplantation across histocompatibility barriers, stem cell expansion, and prevention of complications and generation of graft-vs-tumor activity to eradicate residual disease.

Stem Cell Transplantation for Hematologic and Other Disorders, Second Edition. Haematopoietic reconstitution after autologous stem cell transplantation (ASCT) was evaluated at different times in 26 lymphoma patients. All of the patients showed a significant decrease in the.

The conditioning regimen: destroying the disease. In preparation for allogeneic stem cell transplantation, the recipient undergoes a conditioning regimen of high-dose chemotherapy and, in some cases, radiotherapy to eradicate the underlying malignant disease and to suppress the recipient's immune system so that it will not reject the donor's stem by: High-Dose Therapy and Autologous Hematopoietic Stem-Cell Transplantation Does Not Increase the Risk of Second Neoplasms for Patients With Hodgkin's Lymphoma: A Comparison of Conventional Therapy.

Hematopoietic stem cells (HSCs) are multipotent precursors that have self‐renewal capacity and the ability to regenerate all the different cell types that comprise the blood‐forming system (Bonnet, ; McCulloch and Till, ).

Transplantation of HSCs forms the basis of consolidation therapy in cancer treatments and is used to cure or.

The use of autologous haematopoietic stem cell transplantation as a first line disease modifying therapy in patients with ‘aggressive’ multiple sclerosis.

Mult Scler. ;– Google Cited by: 3. Stephen J. Forman, MD Chair, Department of Hematology and Hematopoietic Cell Transplantation City of Hope Comprehensive Cancer Center Duarte, CA, USA.

Robert S. Negrin, MD Professor of Medicine Chief, Division of Blood and Marrow Transplantation Stanford University Stanford, CA, USA. Joseph H. Antin, MD Professor of Medicine, Harvard Medical.

Childhood hematopoietic cell transplantation involves the infusion of blood stem cells into a patient to reconstitute the blood system. Get detailed information about autologous and allogeneic transplant, HLA matching, preparative regimens, and complications in this summary for clinicians.

3 Understanding The Stem Cell Transplantation Process human leukocyte antigens (HLA) proteins found on the surface of the blood cells that are used to match a patient with a donor for a stem cell transplant infertility the inability to have children infusion the process of putting (transplanting) the stem cells into the patient’s bloodstreamFile Size: 3MB.

Purpose To determine the incidence of second malignancies among patients with Hodgkin's lymphoma (HL) treated with autologous hematopoietic stem cell transplantation (AHSCT) compared with patients receiving conventional therapy alone and to identify potential risk factors for their occurrence.

Patients and Methods We analyzed data on 1, Cited by: High-dose therapy as part of conditioning regimen for stem cell transplantation with myelodepletion and elimination of host lymphoid cells did not result in cure of HIV-1 infection, but an intriguing possibility is the potential to cure HIV-1 infection by using stem cell transplantation with HIV-resistant stem cells, 12 Options for this Author: Liana Nikolaenko, Amrita Krishnan.

Autologous Haematopoietic Stem Cell Transplantation. Autologous HSCT is defined as “a high dose chemotherapy followed by the reinfusion of the patient’s own HSC” (cit. NCI Dictionary). After mobilization (see Chap. 5), the Cited by: 1. A powerpoint presentation created by Jasvir Kaur and Maddie Spinelli describes stem cells in general, hematopoietic stem cells, methods.

Bone marrow transplant (hematopoietic stem cell transplant) (HPSCT) involves the administration of healthy hematopoietic stem cells in patients with dysfunctional or depleted bone marrow. This helps to augment bone marrow function and allows, depending on the disease being treated, to either destroy tumor cells with malignancy or to generate functional cells that can replace the Author: Karam Khaddour, Prerna Mewawalla.

Nademanee A, Sniecinski I, Schmidt GM, et al. High-dose therapy followed by autologous peripheral-blood stem-cell transplantation for patients with Hodgkin's disease and non-Hodgkin's lymphoma using unprimed and granulocyte colony-stimulating factor-mobilized peripheral-blood stem cells.

J Clin Oncol ; Kyriakou C, Canals C, Sibon D, Cahn JY, Kazmi M, Arcese W, Kolbe K, Gorin NC, Thomson K, Milpied N, Niederwieser D, Indrak K, Corradini P, Sureda A, Schmitz N. High-dose therapy and autologous stem-cell transplantation in Waldenstrom macroglobulinemia: the Lymphoma Working Party of the European Group for Blood and Marrow by: 2.

The original editor, Donnall Thomas, was a pioneer in stem cell research and won the Nobel Prize for his discoveries concerning organ and cell transplantation in the treatment of human diseases.

The book also now includes a fully searchable CD with PDFs of the entire content. lab of haematopoietic stem cells blood cancers and cellular therapy Laboratory of Haematopoietic Stem Cells, Blood Cancers and Cellular Therapy Our research has focused on expanding or replacing the role of haematopoietic and mesenchymal stromal cells to enhance haematopoietic recovery after high-dose chemotherapy and transplantation as.

To date, there have been only 2 published prospective randomized studies comparing high-dose with conventional-dose therapy for MM. 18,26 The first study used bone marrow rather than peripheral blood stem cells. As pointed out by both Bladé and Vesole on an intention-to-treat basis, there was a statistically significant improvement in OS for.

Mesenchymal stem cells (MSCs) are multipotent cells that can be expanded and manipulated ex vivo. These cells demonstrated three biological characteristics that qualify them for the use in cellular therapy: (1) potential of differentiation, (2) secretion of trophic factors and (3) immunoregulatory properties.

The bone marrow (BM) has been considered as the traditional Author: Teresa de Souza Fernandez, Cecília de Souza Fernandez. A stem cell transplant can take a few months to complete.

The process begins with treatment of high doses of chemotherapy, radiation therapy, or a combination of the two. This treatment goes on for a week or two. Once you have finished, you will have a few days to rest.

Next, you will receive the blood-forming stem cells. The stem cells will be. High-dose (HD) chemotherapy followed by autologous blood stem-cell transplantation (ASCT) is the standard of care and a highly effective therapy for multiple myeloma (MM) [1, 2].Although HD/ASCT was initially established as a single therapy for first-line treatment of MM [3, 4], subsequent randomized trials demonstrated an overall survival benefit with tandem ASCT, Author: Sandra Sauer.

Total body irradiation (TBI) is a form of radiotherapy used primarily as part of the preparative regimen for haematopoietic stem cell (or bone marrow) the name implies, TBI involves irradiation of the entire body, though in modern practice the lungs are often partially shielded to lower the risk of radiation-induced lung injury.

Purpose We investigated the efficacy and safety of administering high-dose rituximab (HD-R) in combination with high-dose carmustine, cytarabine, etoposide, and melphalan chemotherapy and autologous stem-cell transplantation (SCT) in patients with recurrent B-cell aggressive non-Hodgkin’s lymphoma (NHL).

Patients and Methods Sixty-seven consecutive patients were Cited by:. An autologous stem cell transplant involves storing your stem cells, then giving them back to you after high dose treatment. Donor stem cell (allogeneic) transplants. A donor stem cell transplant replaces bone marrow that is not working properly with stem cells from another person (a donor).

How we can help. Macmillan Cancer Support Line.You then have high-dose chemotherapy to kill your lymphoma. This also damages the rest of the stem cells in your bone marrow. After the chemotherapy, your stored stem cells are thawed and given back to you.

This kind of treatment is sometimes called ‘high-dose therapy and stem cell support’ or ‘high-dose therapy and stem cell rescue’.Intense immunosuppression followed by autologous haematopoietic stem-cell transplantation has been assessed over the past few years as a possible new therapeutic strategy in severe forms of multiple sclerosis.

Pioneering studies began inand since then, more than patients worldwide have been treated with this procedure. Small uncontrolled studies show that about Cited by: